A novel one-pot three-step synthesis of 2-(1-Benzofuran-2-yl)quinoline-3-carboxylic acid derivatives
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چکیده
منابع مشابه
First synthesis of 2-(benzofuran-2-yl)-6,7-methylene dioxyquinoline-3-carboxylic acid derivatives
A facile and inexpensive synthesis of a series of novel methylenedioxy-bearing 2-(benzofuran-2-yl)-quinoline-3-carboxylic acid derivatives 3a-h via the one-pot reaction of ethyl 2-chloromethyl-6,7-methylenedioxyquinoline-3-carboxylate (5) with various substituted salicylaldehydes 6a-g as well as 2-hydroxy-1-naphthaldehyde (6h) is described. Substrate 5 was synthesized by the Friedländer condens...
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Reaction of 3,4,5,6-tetrahydro-2-pyrimidinethiol, prepared by cyclocondensation reaction of 1,3-diamino propane 1 and carbon disulfide, with ethyl chloroacetate and substituted aromatic aldehydes in the presence of sodium acetate and acetic acid gave 2-[(Z)-1-(aryl)]-6,7-dihydro-2H-isothiazolo[2,3-a]pyrimidine-3(5H)-one derivatives 3(a-j) in good yields. 1H-NMR spectroscopy, and elemental analy...
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Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oC. Current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.In conclusion, we have explo...
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Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.
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Barium salts of dibenzylidene cystines 8a-c were obtained from the reaction of Lcystine with benzaldehyde or its derivatives in the presence of barium hydroxide. Their reduction with zinc and hydrochloric acid in methanol yielded the Narylmethylcysteines ?9a-c?. These can, in turn, be converted by esterification into the methyl esters ?10 a-c. ?Reaction of N, N'-carbonyl diimidazole (Im C...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2010
ISSN: 0103-5053
DOI: 10.1590/s0103-50532010000500007